Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Details 3)

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STOCK-BASED COMPENSATION (Details 3) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Share-based Compensation, Stock Options, Activity [Line Items]    
Granted - Weighted Average Exercise Price (in dollars per share) $ 2.99 $ 1.91
Stock Option Activity [Member]    
Share-based Compensation, Stock Options, Activity [Line Items]    
Outstanding - Number of Shares Issuable Upon Exercise of Outstanding Options 53,165 47,133
Granted - Number of Shares Issuable Upon Exercise of Outstanding Options 184,129 11,230
Exercised - Number of Shares Issuable Upon Exercise of Outstanding Options   (2,083)
Expired- Number of Shares Issuable Upon Exercise of Outstanding Options (2,344) (201)
Forfeited - Number of Shares Issuable Upon Exercise of Outstanding Options (2,607) (2,914)
Outstanding - Number of Shares Issuable Upon Exercise of Outstanding Options 232,343 53,165
Exercisable - Number of Shares Issuable Upon Exercise of Outstanding Options 45,448  
Unvested - Number of Shares Issuable Upon Exercise of Outstanding Options 186,895  
Outstanding - Weighted Average Exercise Price (in dollars per share) $ 73.82 $ 75.90
Granted - Weighted Average Exercise Price (in dollars per share) 2.99 19.10
Exercised - Weighted Average Exercise Price (in dollars per share)   14.80
Expired- Weighted Average Exercise Price (in dollars per share) 463.16 1,166.10
Forfeited - Weighted Average Exercise Price (in dollars per share) 19.46 14.80
Outstanding - Weighted Average Exercise Price (in dollars per share) 14.37 $ 73.82
Exercisable - Weighted Average Exercise Price (in dollars per share) 51.97  
Unvested - Weighted Average Exercise Price (in dollars per share) $ 5.23  
Exercisable - Weighted Average Remaining Contracted Term in Years 7 years 10 months 6 days  
Unvested - Weighted Average Remaining Contracted Term in Years 9 years 7 months 24 days  
Exercisable - Aggregate Intrinsic Value (in dollars) $ 0  
Unvested - Aggregate Intrinsic Value (in dollars) $ 0