Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Details 1)

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STOCK-BASED COMPENSATION (Details 1) - USD ($)
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation $ 721,209 $ 758,757
Employee and director stock option grants [Member] | Research and development [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation 94,865 147,821
Employee and director stock option grants [Member] | General and administrative [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation $ 626,344 $ 610,936