Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Tables)

v3.10.0.1
STOCK-BASED COMPENSATION (Tables)
 12 Months Ended
Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block] The following table summarizes the restricted stock grants:
 
 
Number of

Shares
 
 
Weighted

Average

Grant Date

Fair Value
Per Share
 
 
Total Grant

Date Fair

Value
 
Outstanding at December 31, 2016
 
 
—
 
 
 
—
 
 
 
—
 
Granted
 
 
46,000
 
 
$
20.96
 
 
$
964,000
 
Vested
 
 
—
 
 
 
—
 
 
 
—
 
Forfeited
 
 
(8,000
)
 
 
21.00
 
 
 
(168,000
)
Outstanding at December 31, 2017
 
 
38,000
 
 
 
20.95
 
 
 
796,000
 
Granted
 
 
—
 
 
 
—
 
 
 
—
 
Vested
 
 
(12,665
)
 
 
20.95
 
 
 
(265,000
)
Forfeited
 
 
(6,667
)
 
 
20.80
 
 
 
(139,000
)
Outstanding at December 31, 2018
 
 
18,668
 
 
$
21.00
 
 
$
392,000
 
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
The following table summarizes amounts charged to expense for stock-based compensation related to employee and director stock option grants:
 
 
 
Year Ended December 31,
 
 
 
2018
 
 
2017
 
Employee and director stock options and stock grants:
 
 
 
 
 
 
 
 
Research and development
 
$
94,865
 
 
$
147,821
 
General and administrative
 
 
626,344
 
 
 
610,936
 
Total stock-based compensation
 
$
721,209
 
 
$
758,757
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
The following table summarizes weighted-average values and assumptions used for options granted to employees, directors and consultants in the periods indicated:
 
 
 
Year Ended December 31,
 
 
 
2018
 
 
2017
 
Volatility
 
 
91-106
%
 
 
107-110
%
Risk-free interest rate
 
 
2.64-3.05
%
 
 
1.89-2.18
%
Expected life (years)
 
 
6
 
 
 
6
 
Dividend
 
 
0
%
 
 
0
%
Weighted-average exercise price
 
$
2.99
 
 
$
1.91
 
Weighted-average grant-date fair value
 
$
2.30
 
 
$
1.58
 
Share-based Compensation, Stock Options, Activity [Table Text Block]
A summary of stock option activity is as follows:
 
 
 
Number of

Shares

Issuable Upon

Exercise of

Outstanding

Options
 
 
Weighted

Average

Exercise

Price
 
 
Weighted

Average

Remaining

Contracted

Term in

Years
 
 
Aggregate

Intrinsic

Value
 
Outstanding at December 31, 2016
 
 
47,133
 
 
$
75.90
 
 
 
 
 
 
 
 
 
Granted
 
 
11,230
 
 
$
19.10
 
 
 
 
 
 
 
 
 
Exercised
 
 
(2,083
)
 
$
14.80
 
 
 
 
 
 
 
 
 
Expired
 
 
(201
)
 
$
1,166.10
 
 
 
 
 
 
 
 
 
Forfeited
 
 
(2,914
)
 
$
14.80
 
 
 
 
 
 
 
 
 
Outstanding at December 31, 2017
 
 
53,165
 
 
$
73.82
 
 
 
 
 
 
 
 
 
Granted
 
 
184,129
 
 
$
2.99
 
 
 
 
 
 
 
 
 
Expired
 
 
(2,344
)
 
$
463.16
 
 
 
 
 
 
 
 
 
Forfeited
 
 
(2,607
)
 
$
19.46
 
 
 
 
 
 
 
 
 
Outstanding at December 31, 2018
 
 
232,343
 
 
$
14.37
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exercisable, December 31, 2018
 
 
45,448
 
 
$
51.97
 
 
 
7.85
 
 
$
—
 
Unvested, December 31, 2018
 
 
186,895
 
 
$
5.23
 
 
 
9.65
 
 
$
—