Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION

v3.8.0.1
STOCK-BASED COMPENSATION
12 Months Ended
Dec. 31, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
9.  STOCK-BASED COMPENSATION
 
Increase in 2015 Stock Incentive Plan. At the 2017 annual meeting of stockholders held on May 31, 2017, the Company’s stockholders approved an increase in the number of shares of common stock available for issuance under our 2015 Stock Incentive Plan by 1,200,000 shares.
 
2015 Stock Incentive Plan. The 2015 Stock Incentive Plan was adopted on June 9, 2015 authorizing an aggregate of 420,00 shares for issuance (after taking into account the 2016 10:1 reverse stock split). On May 31, 2017, our stockholders approved the Amended and Restated 2015 Stock Incentive Plan (the “2015 Plan”) to increase the authorized shares by 1,200,000 shares. A total of 1,620,000 shares of common stock are authorized for issuance under the 2015 Plan for grants of incentive or nonqualified stock options, rights to purchase restricted and unrestricted shares of common stock, stock appreciation rights and performance share grants. A committee of the board of directors determines exercise prices, vesting periods and any performance requirements on the date of grant, subject to the provisions of the Plan.  Options are granted at or above the fair market value of the common stock at the grant date and expire on the tenth anniversary of the grant date.  Vesting periods are generally between one and four years.  Options granted pursuant to the Plan generally will become fully vested upon a termination event occurring within one year following a change in control, as defined.  A termination event is defined as either termination of employment or services other than for cause or constructive termination of employees or consultants resulting from a significant reduction in either the nature or scope of duties and responsibilities, a reduction in compensation or a required relocation. Upon adoption of the 2015 Plan, shares were no longer available for grant under our 2006 Stock Incentive Plan (the “2006 Plan”). All outstanding awards under the 2006 Plan remained in effect according to the terms of the 2006 Plan and the respective agreements relating to such awards. In addition, any shares that are currently available under the 2006 Plan and any shares underlying awards under the 2006 Plan which are forfeited, cancelled, reacquired by the Company or otherwise terminated will be added to the number of shares available for grant under the 2015 Plan. As of December 31, 2017, there are an aggregate of 869,766 shares available for future grants under the 2015 Plan.
 
2006 Stock Option Plan.  Prior to the approval of the 2015 Stock Incentive Plan, option grants to directors and employees were made under the 2006 Plan.  A total of 70,000 shares of common stock were authorized for issuance under the 2006 Plan for grants of incentive or nonqualified stock options, rights to purchase restricted and unrestricted shares of common stock, stock appreciation rights and performance share grants.  A committee of the board of directors determined exercise prices, vesting periods and any performance requirements on the date of grant, subject to the provisions of the 2006 Plan.  Options were granted at or above the fair market value of the common stock at the grant date and expire on the tenth anniversary of the grant date.  Vesting periods were generally between one and four years. 
 
Restricted Stock Grants. During 2017, the Company issued 460,000 shares under the 2015 Plan of restricted common stock with a weighted average grant date fair value of $2.10. The shares vest annually over a three year period. The following table summarizes the restricted stock grants:
 
Outstanding at December 31, 2016
 
 
 
Granted
 
 
460,000
 
Vested
 
 
 
 Forfeited
 
 
(80,000
)
Outstanding at December 31, 2017
 
 
380,000
 
 
Accounting for Stock-Based Compensation
 
The following table summarizes amounts charged to expense for stock-based compensation related to employee and director stock option grants and recorded in connection with stock options granted to non-employee consultants:
 
 
 
Year Ended December 31,
 
 
 
2017
 
 
2016
 
Employee and director stock options and stock grants:
 
 
 
 
 
 
 
 
Research and development
 
$
147,821
 
 
$
58,044
 
General and administrative
 
 
610,936
 
 
 
471,453
 
 
 
 
758,757
 
 
 
529,497
 
Non-employee consultant stock option grants:
 
 
 
 
 
 
 
 
Research and development
 
 
 
 
 
(338
)
General and administrative
 
 
 
 
 
 
 
 
 
 
 
 
(338
)
Total stock-based compensation
 
$
758,757
 
 
$
529,159
 
 
Assumptions Used In Determining Fair Value
 
Valuation and amortization method. The fair value of each stock award is estimated on the grant date using the Black-Scholes option-pricing model.  The estimated fair value of employee stock options is amortized to expense using the straight-line method over the required service period which is generally the vesting period. The estimated fair value of the non-employee options is amortized to expense over the period during which a non-employee is required to provide services for the award (usually the vesting period).
 
Volatility. The Company estimates volatility based on an average of (1) the Company’s historical volatility since its common stock has been publicly traded and (2) review of volatility estimates of publicly held drug development companies with similar market capitalizations.
 
Risk-free interest rate. The risk-free interest rate is based on the U.S. Treasury yield curve in effect at the time of grant commensurate with the expected term assumption.
 
Expected term. The expected term of stock options granted is based on an estimate of when options will be exercised in the future. The Company applied the simplified method of estimating the expected term of the options, as described in the SEC’s Staff Accounting Bulletins 107 and 110, as the historical experience is not indicative of the expected behavior in the future. The expected term, calculated under the simplified method, is applied to groups of stock options that have similar contractual terms. Using this method, the expected term is determined using the average of the vesting period and the contractual life of the stock options granted. The Company applied the simplified method to non-employees who have a truncation of term based on termination of service and utilizes the contractual life of the stock options granted for those non-employee grants which do not have a truncation of service.
  
Forfeitures.  The Company records stock-based compensation expense only for those awards that are expected to vest. A forfeiture rate is estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from initial estimates. An annual forfeiture rate of 2% was applied to all unvested options for employees and directors, respectively, during the periods ended December 31, 2017 and 2016.  Ultimately, the actual expense recognized over the vesting period will be for only those shares that vest.
 
The following table summarizes weighted-average values and assumptions used for options granted to employees, directors and consultants in the periods indicated:
 
 
 
Year Ended December 31,
 
 
 
2017
 
 
2016
 
Volatility
 
 
107-110
%
 
 
104-105
%
Risk-free interest rate
 
 
1.89-2.18
%
 
 
1.29-1.39
%
Expected life (years)
 
 
6
 
 
 
6
 
Dividend
 
 
0
%
 
 
0
%
Weighted-average exercise price
 
$
1.91
 
 
$
1.97
 
Weighted-average grant-date fair value
 
$
1.58
 
 
$
1.59
 
 
Stock Option Activity
 
A summary of stock option activity is as follows:
 
 
 
Number of
Shares
Issuable Upon
Exercise of
Outstanding
Options
 
 
Weighted
Average
Exercise
Price
 
 
Weighted
Average
Remaining
Contracted
Term in
Years
 
 
Aggregate
Intrinsic
Value
 
Outstanding at December 31, 2015
 
 
70,933
 
 
$
78.63
 
 
 
 
 
 
 
 
 
Granted
 
 
475,300
 
 
$
1.97
 
 
 
 
 
 
 
 
 
Exercised
 
 
(166
)
 
$
1.48
 
 
 
 
 
 
 
 
 
Expired
 
 
(16,153
)
 
$
156.53
 
 
 
 
 
 
 
 
 
Forfeited
 
 
(58,481
)
 
$
7.00
 
 
 
 
 
 
 
 
 
Outstanding at December 31, 2016
 
 
471,433
 
 
$
7.59
 
 
 
 
 
 
 
 
 
Granted
 
 
112,300
 
 
$
1.91
 
 
 
 
 
 
 
 
 
Exercised
 
 
(20,833
)
 
$
1.48
 
 
 
 
 
 
 
 
 
Expired
 
 
(2,004
)
 
$
116.61
 
 
 
 
 
 
 
 
 
Forfeited
 
 
(29,167
)
 
$
1.48
 
 
 
 
 
 
 
 
 
Outstanding at December 31, 2017
 
 
531,729
 
 
6.55
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Vested, December 31, 2017
 
 
254,777
 
 
$
9.79
 
 
 
8.27
 
 
$
 
Unvested, December 31, 2017
 
 
276,952
 
 
$
3.57
 
 
 
8.72
 
 
$
 
Exercisable at December 31, 2017
 
 
254,777
 
 
$
9.79
 
 
 
8.27
 
 
$
 
 
Exercise prices for all grants made during the twelve months ended December 31, 2017 and 2016 were equal to or greater than the market value of the Company’s common stock on the date of grant. The aggregate intrinsic value of options outstanding is calculated based on the positive difference between the estimated per-share fair value of common stock at the end of the respective period and the exercise price of the underlying options. Shares of common stock issued upon the exercise of options are from authorized but unissued shares.
 
The weighted-average grant-date fair value of options granted during the years ended December 31, 2017 and 2016 was $1.58 and $1.59, respectively.  The total fair value of shares vested during the years ended December 31, 2017 and 2016 was $636,071 and $440,443, respectively.  The weighted-average grant-date fair value of vested and unvested options outstanding at December 31, 2017 was $7.74 and $2.91, respectively. The weighted-average grant-date fair value of vested and unvested options outstanding at December 31, 2016 was $20.03 and $3.27, respectively.
  
The weighted average grant date fair value of options expired during the years ended December 31, 2017 and December 31, 2016 was $61.12 and $116.32, respectively. The weighted average grant date fair value of options forfeited during the years ended December 31, 2017 and December 31, 2016 was $1.19 and $2.54, respectively. The number of options vested during the years ended December 31, 2017 and December 31, 2016 was 203,608 and 68,180, respectively. The number of options unvested at January 1, 2017 and January 1, 2016 was 397,427 and 47,253, respectively. The weighted average grant date fair value of options unvested at January 1, 2017 and January 1, 2016 was $3.27 and $23.93, respectively.
 
As of December 31, 2017, there was $1,218,812 of total unrecognized compensation cost related to unvested stock-based compensation arrangements.  Of this total amount, the Company expects to recognize $672,865, $474,340, and $71,607 during 2018, 2019, and 2020 respectively. The Company expects options to purchase 643,813 shares to vest in the future.