Quarterly report pursuant to Section 13 or 15(d)

STOCK-BASED COMPENSATION (Details)

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STOCK-BASED COMPENSATION (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]        
Total stock-based compensation $ 175,579 $ 231,086 $ 349,017 $ 396,760
Employee and director stock option grants [Member] | Research and development [Member]        
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]        
Total stock-based compensation 36,625 40,072 70,752 56,720
Employee and director stock option grants [Member] | General and administrative [Member]        
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]        
Total stock-based compensation $ 138,954 $ 191,014 $ 278,265 $ 340,040