Quarterly report pursuant to Section 13 or 15(d)

STOCK-BASED COMPENSATION (Tables)

v3.10.0.1
STOCK-BASED COMPENSATION (Tables)
6 Months Ended
Jun. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
The following table summarizes amounts charged to expense for stock-based compensation related to employee and director stock grants and stock option grants and recorded in connection with stock options granted to non-employee consultants:
 
 
 
Three Months Ended
June 30,
 
 
Six Months Ended
June 30,
 
 
 
2018
 
 
2017
 
 
2018
 
 
2017
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Employee and director stock and stock option grants:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Research and development
 
$ 36,625
 
 
$ 40,072
 
 
$ 70,752
 
 
$ 56,720
 
General and administrative
 
 
138,954
 
 
 
191,014
 
 
 
278,265
 
 
 
340,040
 
Total stock-based compensation
 
$ 175,579
 
 
$ 231,086
 
 
$ 349,017
 
 
$ 396,760
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
A summary of stock option activity is as follows:
 
 
 
Number of Shares Issuable Upon Exercise of Outstanding Options
 
 
Weighted Average Exercise Price
 
 
Weighted Average Remaining Contracted Term in Years
 
 
Aggregate Intrinsic Value
 
Outstanding at December 31, 2017
 
 
53,172
 
 
$ 65.50
 
 
 
 
 
 
 
 
 
   Granted
 
 
8,000
 
 
$ 11.70
 
 
 
 
 
 
 
 
 
   Expired
 
 
(1,550 )
 
$ 349.20
 
 
 
 
 
 
 
 
 
   Forfeited
 
 
(2,096 )
 
$ 19.30
 
 
 
 
 
 
 
 
 
Outstanding at June 30, 2018
 
 
57,526
 
 
$ 52.10
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exercisable, June 30, 2018
 
 
32,131
 
 
$ 72.90
 
 
 
7.82
 
 
$
 
Unvested, June 30, 2018
 
 
25,395
 
 
$ 25.70
 
 
 
8.73
 
 
$
 
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] A summary of restricted stock activity is as follows:
 
Outstanding non-vested restricted stock at December 31, 2017
 
 
38,000
 
Granted
 
 
 
Vested
 
 
(12,666 )
Outstanding non-vested restricted stock at June 30, 2018
 
 
25,334