Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Details)

v3.5.0.2
STOCK-BASED COMPENSATION (Details) - USD ($)
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation $ 447,300 $ 850,350
Employee and Director Stock Option Grants [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation 448,158 844,082
Employee and Director Stock Option Grants [Member] | Research and development [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation 130,901 174,666
Employee and Director Stock Option Grants [Member] | General and administrative [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation 317,257 621,563
Employee and Director Stock Option Grants [Member] | Restructuring costs [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation 0 47,853
Non Employee Consultant Stock Option Grants [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation (858) 6,268
Non Employee Consultant Stock Option Grants [Member] | Research and development [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation (858) 6,268
Non Employee Consultant Stock Option Grants [Member] | General and administrative [Member]    
Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Line Items]    
Total stock-based compensation $ 0 $ 0