Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Details)

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STOCK-BASED COMPENSATION (Details) - USD ($)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Employee and director stock option grants:    
Total stock-based compensation $ 1,452,964 $ 1,124,190
Employee and director stock option grants | Research and development    
Employee and director stock option grants:    
Total stock-based compensation 165,461 117,805
Employee and director stock option grants | General and administrative    
Employee and director stock option grants:    
Total stock-based compensation $ 1,287,502 $ 1,006,385