Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Total
Preferred Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Accumulated Deficit [Member]
BALANCE AT DECEMBER at Dec. 31, 2016 $ 13,539,872 $ 865,136 $ 10 $ 83,461,752 $ (70,787,026)
BALANCE AT DECEMBER (in shares) at Dec. 31, 2016   17 1,036,832    
Issuance of common stock, warrants and preferred stock, net of issuance costs 7,054,865 $ 2,265,257 $ 2 4,789,606 0
Issuance of common stock, warrants and preferred stock, net of issuance costs (in shares)   41 195,438    
Warrant exercises 2,963,259 $ 0 $ 2 2,963,257 0
Warrant exercises (in shares)   0 197,550    
Stock-based compensation 758,757 $ 0 $ 0 758,757 0
Cashless option exercise 0 $ 0 $ 0 0 0
Cashless option exercise (in shares)   0 240    
Conversion of preferred shares into common shares 0 $ (2,134,611) $ 2 2,134,609 0
Conversion of preferred shares into common shares (in shares)   (40) 236,084    
Net loss (13,562,290) $ 0 $ 0 0 (13,562,290)
BALANCE AT DECEMBER at Dec. 31, 2017 10,754,463 $ 995,782 $ 16 94,107,981 (84,349,316)
BALANCE AT DECEMBER (in shares) at Dec. 31, 2017   18 1,666,144    
Issuance of common stock, warrants and preferred stock, net of issuance costs 15,025,078 $ 5,949,301 $ 14 9,075,763 0
Issuance of common stock, warrants and preferred stock, net of issuance costs (in shares)   1,114 1,355,000    
Stock-based compensation 721,209 $ 0 $ 0 721,209 0
Vested restricted stock 0 $ 0 $ 0 0 0
Vested restricted stock (in shares)   0 12,667    
Reverse stock split fractional shares (762) $ 0 $ 0 (762) 0
Reverse stock split fractional shares (in shares)   0 (105)    
Retired shares 0 $ 0 $ 0 0 0
Retired shares (in shares)   0 (104)    
Conversion of preferred shares into common shares 0 $ (4,419,034) $ 17 4,419,017 0
Conversion of preferred shares into common shares (in shares)   (659) 1,698,785    
Net loss (13,239,027) $ 0 $ 0 0 (13,239,027)
BALANCE AT DECEMBER at Dec. 31, 2018 $ 13,260,961 $ 2,526,049 $ 47 $ 108,323,208 $ (97,588,343)
BALANCE AT DECEMBER (in shares) at Dec. 31, 2018   473 4,732,387